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Research Overview

Projects

  • Ischemia distribution across the left ventricular wall

    Literature suggests that myocardial ischemia originates from the sub-endocardial region. Is this always true?

  • Ischemia progression from non-transmural to full thickness

    The current state of the art also suggests that ischemia progresses uniformly from the sub-endocardium to the epicardium as a wavefront resulting in transmural ischemia. Is this characterization accurate?

  • Biophyiscal basis for ST depression on cardiac surface

    ST depression on the cardiac surface (Electrogram) and by extension on the body surface (ECG) is believed to be the result of sub-endocardial ischemia. How accurate is this model of diagnosis?

  • Ischemic response under demand and supply conditions

    An ischemic stress condition can be reached by reducing blood flow to the heart (supply ischemia) or increasing metabolic load on the heart (demand ischemia). Does the path (supply or demand) affect the electrographical response of the heart under the same ischemic stress condition?

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